This study examines what stimulates and sustains commitment of nurses to their profession in the Volta Region of Ghana and whether commitment is shaped by similar variables. A quantitative approach was adopted using a validated questionnaire developed by Blau (1989) and modified by Reilly & Orsak (1991) to fit the nursing profession. A Kruska Wallis test was used to analyse the data with SPSS as an interface. The findings revealed a high commitment rate to the nursing profession in Ghana due to love of the profession and monetary considerations. However, a significant number of nurses are not committed to the profession at all which poses managerial and theoretical implications.