Few studies have actually investigated the competitive challenges that Chinese multinational companies (MNCs) face in Ghana to understand the reasons for their challenges, their implications for Ghana’s socioeconomic development and the strategies for managing these challenges. This paper partly fills this important research gap by exploring the competitive challenges facing Chinese MNCs in Ghana using a multiple embedded case study design. The qualitative data was analysed using content analysis. The findings reveal that Chinese MNCs currently face a myriad of competitive challenges. Different reasons are provided for these challenges as well as their implications for Ghana’s socioeconomic development. Strategies for managing these challenges are also well suggested.